Understanding GLP-1 Medications
Do you have questions about GLP-1 Medications? Glucagon- like peptide-1 agonist (GLP-1) medications have attracted increased attention in the past several years for treatment of type 2 Diabetes and weight loss management. Although, using these medications alone can lead to improvements in health and weight, using a guided integrative approach with support and oversight will lead to more successful lasting outcomes. Read more to understand these medications and how they could benefit you.
Semaglutide and other GLP-1 agonists are the synthetic version of a naturally occurring hormone made up of a string of amino acids produced by the cells in the intestine in response to food intake stimulating the release of insulin and inhibiting glucagon secretion and signaling the feeling of fullness contributing to glucose metabolism and energy regulation. GLP-1 agonist medications are chemically derived peptides acting as GLP-1 activating the receptors, enhancing insulin productions, decreasing glucagon secretion and delaying gastric emptying. They also act within the brain pathways to regulate appetite and satiety. Much research has been done with this class of medications showing the benefits on weight and insulin resistance.
Tirzepatide is a dual agonist that is a combination of both a GLP-1 agonist and a glucose dependent insulinotropic polypeptide (GIP). What does this mean? In short it combines the benefits of a GLP-1 agonist with another peptide that also is released within the intestines acting on similar pathways creating an incretin effect that provides improved insulin sensitivity and appetite control than GLP-1 agonists alone. The Incretin pathway has been found to be decreased or not existent in those with type 2 diabetes and use of this medication will stimulate those pathways to allow for more successful management of diabetes, obesity and overall metabolic health. Both medications can offer several key benefits.
1.) Blood sugar regulation and insulin sensitivity: This is done by stimulating insulin secretion and the body’s response, decreasing insulin resistance and helping to restore blood sugar levels. This is important not only for diabetes management but for overall metabolic function affecting other chronic conditions such as heart disease, metabolic syndromes, and obesity.
2.) Weight loss and appetite control:
As already mentioned, GLP-1 agonist medications help with reduction of appetite and satiety. This is done by stimulating delayed gastric emptying thereby reducing appetite. There is evidence that GLP-1 receptors in the brain are affected by quieting the “food noise” and helping to curb craving. Research has shown that GIP/GLP-1 agonist such as Tirzepatide provides more weight loss and fat loss than a GLP-1 agonist medication alone. This is important in obesity management for those who may not have been diagnosed with type 2 diabetes but are still looking for help with weight loss. will help to restore a more balanced metabolism by addressing insulin resistance and hunger hormones.
3.) REDUCTION IN INFLAMMATION AND CARDIOVASCULAR RISK:
GLP-1 medications have the added benefit of anti-inflammatory effects as it decreases the release of proinflammatory cytokines that lead to systemic inflammation and allowing for reperfusion of the microvasculature structures damaged by inflammation. GLP-1 medications affect the gut microbiome in a positive way as it is naturally produced in the gut. Enhancing natural pathways, increasing growth of good gut bacteria, improving digestion, and repairing the integrity of the gut lining. Early research has even shown positive benefits towards autoimmune conditions such as rheumatoid arthritis, psoriasis and metabolic disorders like poly cystic ovarian syndrome. This can decrease the risks associated with chronic conditions including diabetes, obesity, heart disease, fatty liver, chronic kidney disease, and autoimmune conditions. Providing yet another tool for managing chronic conditions.
Although there are many benefits to GLP-1 medications there can be side effects and understanding them is important when considering these medications. The adage “low and slow” is important when managing these medications. Standard dosage, using an autoinjector may seem convenient but will often lead to increased negative side effects as the dosing may be too high for the individual. Using carefully vetted compounding pharmacies with experience in peptides allows for lower starting dosages and slower dosage increases. Utilizing this approach allows for a pace that works for the individual's goal with less side effects and increased safety.
Incorporating GLP-1 medications requires careful consideration. At the Stram Center we believe in a holistic approach. This means working closely with a provider to help identify and manage root causes, support lifestyle modifications, and routine monitoring of lab work for safety and efficacy. This is further enhanced by regular 1:1 meetings with our registered dietician and mental health support. These medications offer a helpful tool to individuals struggling with obesity and metabolic dysregulation along with an integrative approach and expert oversight to enhance the natural healing mechanisms for long-term health improvement.
